General Information

  • ID:  hor004238
  • Uniprot ID:  P01015
  • Protein name:  Angiotensin-2
  • Gene name:  AGT
  • Organism:  Rattus norvegicus (Rat)
  • Family:  Serpin family
  • Source:  animal
  • Expression:  Expressed by the liver and secreted in plasma.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0004867 serine-type endopeptidase inhibitor activity; GO:0005179 hormone activity; GO:0031702 type 1 angiotensin receptor binding; GO:0031703 type 2 angiotensin receptor binding
  • GO BP:  GO:0000165 MAPK cascade; GO:0001543 ovarian follicle rupture; GO:0001568 blood vessel development; GO:0001658 branching involved in ureteric bud morphogenesis; GO:0001819 positive regulation of cytokine production; GO:0001822 kidney development; GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin; GO:0001998 angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure; GO:0001999 renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure; GO:0002018 renin-angiotensin regulation of aldosterone production; GO:0002019 regulation of renal output by angiotensin; GO:0002027 regulation of heart rate; GO:0002034 maintenance of blood vessel diameter homeostasis by renin-angiotensin; GO:0002035 brain renin-angiotensin system; GO:0003014 renal system process; GO:0003051 angiotensin-mediated drinking behavior; GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin; GO:0003331 positive regulation of extracellular matrix constituent secretion; GO:0006606 protein import into nucleus; GO:0006883 intracellular sodium ion homeostasis; GO:0007160 cell-matrix adhesion; GO:0007166 cell surface receptor signaling pathway; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007565 female pregnancy; GO:0008065 establishment of blood-nerve barrier; GO:0008217 regulation of blood pressure; GO:0008283 cell population proliferation; GO:0008284 positive regulation of cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0008306 associative learning; GO:0009409 response to cold; GO:0009612 response to mechanical stimulus; GO:0009651 response to salt stress; GO:0010468 regulation of gene expression; GO:0010595 po
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005739 mitochondrion

Sequence Information

  • Sequence:  DRVYIHPF
  • Length:  8
  • Propeptide:  MTPTGAGLKATIFCILTWVSLTAGDRVYIHPFHLLYYSKSTCAQLENPSVETLPEPTFEPVPIQAKTSPVDEKTLRDKLVLATEKLEAEDRQRAAQVAMIANFMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLLGVPVKEGDCTSRLDGHKVLTALQAVQGLLVTQGGSSSQTPLLQSTVVGLFTAPGLRLKQPFVESLGPFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTYVHFQGKMRGFSQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGESVTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKLSTLLGAEANLGKMGDTNPRVGEVLNSILLELQAGEEEQPTESAQQPGSPEVLDVTLSSPFLFAIYERDSGALHFLGRVDNPQNVV
  • Signal peptide:  MTPTGAGLKATIFCILTWVSLTAG
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  Agtr1a
  • Target Unid:  P25095
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P01015-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004238_AF2.pdbhor004238_ESM.pdb

Physical Information

Mass: 117123 Formula: C50H71N13O12
Absent amino acids: ACEGKLMNQSTW Common amino acids: DFHIPRVY
pI: 7.54 Basic residues: 2
Polar residues: 1 Hydrophobic residues: 3
Hydrophobicity: -32.5 Boman Index: -1650
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 85
Instability Index: 2580 Extinction Coefficient cystines: 1490
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  NA
  • Title:  NA